Resveratrol attenuates N-methyl-D-aspartate receptor-mediated activation in substantia gelatinosa neurons of trigeminal subnucleus caudalis in mice
장선희, 조동휴, 한성규,
소속 상세정보
장선희 ( Jang Seon-Hui ) -
조동휴 ( Cho Dong-Hyu ) -
한성규 ( Han Seong-Kyu ) -
Abstract
The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) receives orofacial nociceptive information from primary afferent neurons and transmits this information to higher brain centers. Resveratrol (3, 5, 4′-trihydroxystilbene) is a polyphenolic compound found in various plant species and have been reported to have various biological activities, including analgesic effects. Although many studies have investigated the mechanism of action of resveratrol in terms of its antinociceptive effect, limited research has been conducted on the effects of resveratrol on SG neurons involved in orofacial pain transmission, especially to understand its relevance to glutamate receptors. To address this research gap, the present study investigated the effect of resveratrol on glutamate receptor activity in SG neurons using the whole-cell patch-clamp technique. The results showed that resveratrol significantly inhibited glutamate-mediated inward currents in SG neurons. Notably, there were no changes in α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid- or kainic acid-mediated inward currents in the presence of resveratrol, although N-methyl-D-aspartate (NMDA)-mediated inward currents were markedly suppressed. Taken together, these results suggest that resveratrol may be involved in orofacial pain transmission in SG neurons of the Vc by inhibiting the activity of NMDA receptors, among ionotropic glutamate receptors.
키워드
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; Glutamate; Kainic acid; N-methyl-D-aspartate; Orofacial pain
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